Dr. Dominic Filice’s passion lies at the intersection of cutting-edge medicine, biotechnology, engineering, intellectual property, and business. With diverse interests and experience across the life and physical sciences, Dominic thrives on helping clients build upon their ideas by infusing fresh perspectives with his natural ability to examine a subject from multiple perspectives. Further, he understands the need of business decision makers for clear communication and actionable intelligence, learned first-hand through his managing roles over intellectual property, product development, and strategic marketing at a growing ophthalmology medical device company as well as his work as a patent research consultant.
Prior to passing the 2016 USPTO patent bar examination, Dominic researched the use of stem cells for heart regeneration through his PhD at the University of Washington. At UW, Dominic developed new imaging and analysis technologies to assess the electrical activity and integration of human pluripotent stem cell-derived cardiomyocyte grafts in injured hearts, while also gaining valuable surgical skills that have allowed him to communicate effectively with healthcare professionals across multiple disciplines.
As a patent agent, Dominic has prepared and prosecuted domestic and international patent applications, conducted searches, patent invalidity and patentability analyses, created patent, technology, and market landscape reports, and directed IP matters of M&A due diligence. While he is quick to learn new subject matter, Dominic has direct experience in regenerative medicine and stem cell therapy, medical and surgical devices, surgical procedures, biotechnology, imaging systems and image analysis, ophthalmology, mechanical engineering, and oil and renewable energy production.
Co-author, “How to find an unmet need in the medical device industry and early considerations for pursuing it,” Parola Analytics Inc. (December 2020)
Filice D, Dhahri W, Solan JL, Lampe PD, Steele E, Milani N, Van Biber B, Zhu WZ, Valdman TS, Romagnuolo R, Otero-Cruz JD, Hauch KD, Kay MW, Sarvazyan N, Laflamme MA. Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts. Stem Cell Res Ther. 2020 Sep 25;11(1):417.
Zhu WZ, Filice D, Palpant NJ, Laflamme MA. Methods for assessing the electromechanical integration of human pluripotent stem cell-derived cardiomyocyte grafts. Methods Mol Biol. 2014;1181:229-47.
Lundy SD, Gantz JA, Pagan CM, Filice D, Laflamme MA. Pluripotent stem cell derived cardiomyocytes for cardiac repair. Curr Treat Options Cardiovasc Med. 2014 Jul;16(7):319.
Shiba Y, Filice D, Fernandes S, Minami E, Dupras SK, Biber BV, Trinh P, Hirota Y, Gold JD, Viswanathan M, Laflamme MA. Electrical Integration of Human Embryonic Stem Cell-Derived Cardiomyocytes in a Guinea Pig Chronic Infarct Model. J Cardiovasc Pharmacol Ther. 2014 Jul;19(4):368-381.
Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW, Murry CE, Laflamme MA. Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature. 2012 Sep 13;489(7415):322-5. doi: 10.1038/nature11317.